[Observation on therapeutic effect of electroacupuncture plus blood-letting puncture at Weizhong (BL 40) on acute lumbar disc herniation]

Zhongguo Zhen Jiu. 2009 Feb; 29(2): 123-5Chen HL, Qiu XH, Yan XCOBJECTIVE: To find a better method for treatment of acute lumbar disc herniation. METHODS: One hundred cases were randomly divided into 2 groups. The observation group of 52 cases was treated with electroacupuncture at Yaoyangguan (GV 3), Dachangshu (BL 25), Guanyuanshu (BL 26), Xiaochangshu (BI. 27) as main points, and blood-letting puncture at stagnant collaterals nearby Weizhong (BL 40); the control group of 48 cases was treated with traction combined with electroacupuncture at main points Jiaji (EX-B 2), Shenshu (BL 23), Dachangshu (BL 25). Their therapeutic effects were observed and compared. RESULTS: The cured rate and the cured markedly effective rate were 55.8% and 82.7% in the observation group and 33.3% and 54.2% in the control group, respectively, with significant differences between the two groups (P < 0.05, P < 0.01). CONCLUSION: Electroacupuncture combined with blood letting puncture at stagnant collaterals nearby Weizhong (BL 40) has a signifi cant therapeutic effect on acute lumbar disc herniation.

A systematic review of mechanical lumbar disc decompression with nucleoplasty.

Pain Physician. 2009 May-Jun; 12(3): 561-72Manchikanti L, Derby R, Benyamin RM, Helm S, Hirsch JABACKGROUND: Lumbar disc prolapse, protrusion, or extrusion account for less than 5% of all low back problems, but are the most common causes of nerve root pain and surgical interventions. The primary rationale for any form of surgery for disc prolapse is to relieve nerve root irritation or compression due to herniated disc material. The primary modality of treatment continues to be either open or microdiscectomy, but several alternative techniques including nucleoplasty, automated percutaneous discectomy, and laser discectomy have been described. There is a paucity of evidence for all decompression techniques, specifically alternative techniques including nucleoplasty. STUDY DESIGN: A systematic review of the literature. OBJECTIVE: To determine the effectiveness of mechanical lumbar disc decompression with nucleoplasty. METHODS: A comprehensive evaluation of the literature relating to mechanical lumbar disc decompression with nucleoplasty was performed. The literature was evaluated according to Cochrane review criteria for randomized controlled trials (RCTs), and Agency for Healthcare Research and Quality (AHRQ) criteria was utilized for observational studies. The level of evidence was classified as Level I, II, or III with 3 subcategories in Level II based on the quality of evidence developed by the United States Preventive Services Task Force (USPSTF). A literature search was conducted using only English language literature through PubMed, EMBASE, the Cochrane library, systematic reviews, and cross-references from reviews and systematic reviews. OUTCOME MEASURES: Pain relief was the primary outcome measure. Other outcome measures were functional improvement, improvement of psychological status, opioid intake, and return to work. Short-term effectiveness was defined as one year or less, whereas, long-term effectiveness was defined as greater than one year. RESULTS: Based on USPSTF criteria the level of evidence for nucleoplasty is Level II-3 in managing predominantly lower extremity pain due to contained disc herniation. LIMITATIONS: Paucity of literature, both observational and randomized. CONCLUSION: This systematic review illustrates Level II-3 evidence for mechanical lumbar percutaneous disc decompression with nucleoplasty in treatment of leg pain. However, there is no evidence available in managing axial low back pain.

Automated percutaneous lumbar discectomy for the contained herniated lumbar disc: a systematic assessment of evidence.

Pain Physician. 2009 May-Jun; 12(3): 601-20Hirsch JA, Singh V, Falco FJ, Benyamin RM, Manchikanti LBACKGROUND: Lumbar disc prolapse, protrusion, and extrusion account for less than 5% of all low back problems, but are the most common causes of nerve root pain and surgical interventions. The typical rationale for traditional surgery is an effort to provide more rapid relief of pain and disability. It should be noted that the majority of patients will recover with conservative management. The primary rationale for any form of surgery for disc prolapse associated with radicular pain is to relieve nerve root irritation or compression due to herniated disc material. The primary modality of treatment continues to be either open or microdiscectomy, but several alternative techniques including automated percutaneous lumbar discectomy (APLD) have been described. However, there is a paucity of evidence for all decompression techniques, specifically alternative techniques including automated and laser discectomy. STUDY DESIGN: A systematic review of the literature. OBECTIVE: To determine the effectiveness of APLD. METHODS: A comprehensive evaluation of the literature relating to automated lumbar disc decompression was performed. The literature was evaluated according to Cochrane review criteria for randomized controlled trials (RCTs), and Agency for Healthcare Research and Quality (AHRQ) criteria was utilized for observational studies. A literature search was conducted of English language literature through PubMed, EMBASE, the Cochrane library, systematic reviews, and cross references from reviews and systematic reviews. The level of evidence was classified as Level I, II, or III with 3 subcategories in Level II based on the quality of evidence developed by the United States Preventive Services Task Force (USPSTF). OUTCOME MEASURES: Pain relief was the primary outcome measure. Other outcome measures were functional improvement, improvement of psychological status, opioid intake, and return to work. Short-term effectiveness was defined as one year or less, whereas, long-term effectiveness was defined as greater than one year. RESULTS: Based on USPSTF criteria, the indicated evidence for APLD is Level II-2 for short- and long-term relief. LIMITATIONS: Paucity of RCTs in the literature. CONCLUSION: This systematic review indicated Level II-2 evidence for APLD. APLD may provide appropriate relief in properly selected patients with contained lumbar disc prolapse.

Systematic Review of Percutaneous Lumbar Mechanical Disc Decompression Utilizing Dekompressor(R).

Pain Physician. 2009 May-June; 12(3): 589-599Singh V, Benyamin RM, Datta S, Falco FJ, Helm S, Manchikanti LBACKGROUND: In recent years, a number of minimally invasive nuclear decompression techniques for lumbar disc prolapse, protrusion, and/or herniation have been introduced, including the Dekompressor(R) a device utilizing an Archimedes screw. The primary goal of the surgical treatment of nerve root compression from a disc protrusion continues to be the relief of compression by removing the herniated nuclear material with open discectomy. However, poor results have been reported for contained disc herniations with open surgical interventions. The results with several alternative techniques including the Dekompressor, automated percutaneous discectomy, and laser discectomy have been described, but are not convincing. There is a paucity of evidence for all decompression techniques. STUDY DESIGN: A systematic review of the mechanical disc decompression with Dekompressor literature. OBJECTIVE: The objective of this systematic review is to evaluate the clinical effectiveness of the Dekompressor, a high rotation per minute device utilizing an Archimedes screw, used in mechanical lumbar disc decompression. METHODS: The literature search was conducted utilizing a comprehensive strategy for mechanical disc decompression utilizing the Dekompressor. A literature search was conducted using only English language literature in a comprehensive search of databases including PubMed, EMBASE, the Cochrane Library, along with systematic reviews, and cross-references from reviews, systematic reviews, and individual articles. The quality of the manuscripts included was evaluated according to Cochrane review criteria for randomized controlled trials (RCTs), and for observational studies with the criteria developed by the Agency for Healthcare Research and Quality (AHRQ). The level of evidence developed by the United States Preventive Services Task Force (USPSTF) was utilized in this review. The evidence was classified as Level I, II, or III with 3 subcategories in Level II for a total of 5 levels of evidence. OUTCOME MEASURES: Pain relief was the primary outcome measure. Other outcome measures were functional improvement, improvement of psychological status, opioid intake, and return to work. Short-term effectiveness was defined as one year or less, whereas, long-term effectiveness was defined as greater than one year. RESULTS: Based on USPSTF criteria the indicated level of evidence for the mechanical high RPM device or Dekompressor is Level III for short- and long-term relief. LIMITATIONS: Lack of literature, both randomized and observational. CONCLUSION: This systematic review illustrates Level III evidence for mechanical percutaneous disc decompression procedures with the high RPM device or Dekompressor.

Percutaneous endoscopic lumbar discectomy by transiliac approach: a case report.

Spine. 2009 May 20; 34(12): E443-6Choi G, Kim JS, Lokhande P, Lee SHSTUDY DESIGN: Case report. OBJECTIVE: The authors report a new percutaneous endoscopic lumbar discectomy (PELD) technique for the treatment of lumbar disc herniation with a high iliac crest via a transiliac approach. SUMMARY OF BACKGROUND DATA: When the iliac crest is high, the L4-L5 and L5-S1 disc spaces are located deep in the pelvis, so they are not easily accessible via a suprailiac route. METHODS: A 51-year-old man manifested left gluteal and leg pain due to an up-migrated soft disc herniation at the L4-L5 level. Transforaminal PELD via a transiliac approach was performed to remove the herniated fragment, achieving complete decompression of the nerve root. RESULTS: The symptom was relieved and the patient was discharged the next day. CONCLUSION: When a conventional transforaminal PELD is impossible due to the presence of a high iliac crest, PELD via a transiliac route could be a alternative option in selected cases.

Extraforaminal with or without foraminal disk herniation: reliable MRI findings.

AJR Am J Roentgenol. 2009 May; 192(5): 1392-6Lee IS, Kim HJ, Lee JS, Moon TY, Jeon UBOBJECTIVE: The purpose of our study was to evaluate spinal MR images for extraforaminal disk herniation with or without foraminal disk herniation to determine the reliable MRI findings. MATERIALS AND METHODS: Thirty-five patients with extraforaminal with or without foraminal disk herniation confirmed at radiculography or surgery between March 2005 and July 2007 underwent spinal MRI. We assessed the morphologic features of the disk, changes in nerve root thickness, epidural fat obliteration surrounding the nerve root, and displacement of the nerve root in the foraminal and extraforaminal zones. RESULTS: Mixed disk herniation was found in 23 patients, and purely extraforaminal herniation was found in 12 patients. Focal eccentricity of the disk contour was identified in 32 patients (91%). Change in the nerve root thickness was found in 30 patients (86%). The nerve roots were displaced in 22 patients (63%), and the original location was maintained in nine patients (26%). Differentiation between the disk and the nerve root was poor in four of the 35 patients (11%). Obliteration of the epidural fat surrounding the nerve root was present in all patients. CONCLUSION: The presence of extraforaminal with or without foraminal disk herniation should be ascertained on the basis of the following MRI findings: focal eccentricity of the disk contour, obliteration of epidural fat surrounding the nerve root, change in the thickness of the nerve root, and displacement of the nerve root.

A cervical spine model to predict injury scenarios and clinical instability.

Sports Biomech. 2009 Mar; 8(1): 78-95Tchako A, Sadegh AA complete and detailed three-dimensional finite element model of the human cervical spine (C1-C7), including soft and hard tissues, was created using a digitized geometric measurement tool. The model was validated against existing experimental studies in flexion, extension, lateral bending, and axial rotation. The aims of this study were to use the model to simulate the mechanisms of injury scenarios, such as diving and football accidents, and to correlate the external and internal responses of the spinal components to disc herniation and clinical instability. It was determined that a shear-generated flexion moment of about 10 Nm or a compression-flexion load of 450 N would generate significant stresses and strains in the discs, together with sufficient posterior-anterior displacement and rotational angulation of the vertebrae, to place the mid and lower cervical spine at risk of clinical instability or disc herniation. The results revealed that the location of the maximum stresses in the discs could not be directly correlated with the type of loads. In addition, for the loadings considered, the maximum displacement of the spine could be reduced by as much as 50% when the restraint of the cervical spine is changed from a C7-T1 to C7-T1 and C1-C2 fixed conditions.

Occult dural arteriovenous fistula causing rapidly progressive conus medullaris syndrome and paraplegia after lumbar microdiscectomy.

Spine J. 2009 May 11; Stevens EA, Powers AK, Morris PP, Wilson JABACKGROUND CONTEXT: A spinal dural arteriovenous fistula (DAVF) is a known cause of venous congestive myelopathy. These lesions are thought to be acquired. There exist two prior reports that describe DAVF presenting with slowly progressive myelopathy years after lumbar disc surgery. PURPOSE: We report the first case of a preexistent, asymptomatic DAVF that became acutely symptomatic after lumbar microdiscectomy causing rapidly progressive conus medullaris syndrome and paraplegia. STUDY DESIGN: Case report. METHODS: A 53-year-old Caucasian male presented with urinary retention, fecal incontinence, and progressive loss of function in bilateral lower extremities less than 3 months after a lumbar discectomy at an outside facility. The patient underwent microdiscectomy at L4/L5 and L5/S1 for left-sided radicular symptoms and evidence of herniated discs on magnetic resonance imaging (MRI). The patient's preoperative pain improved after the discectomy, but his bowel, bladder, and lower extremity function deteriorated steadily after discharge. Postoperative MRI showed salient serpentine vessels in the region of L1 and L2 with an enlarged T2 bright conus medullaris. Retrospective review of preoperative MRI revealed the presence of similar but less pronounced findings. A spinal arteriogram confirmed concerns of an arteriovenous malformation. The patient was transferred to our facility for definitive management of his DAVF via catheter embolization. RESULTS: Complete fistula obliteration was confirmed at the time of embolization and at 8 weeks follow-up with selective spinal angiography. The appearance of the conus medullaris normalized on follow-up MRI. The patient made a slow but significant recovery in rehabilitation. He regained the ability to independently ambulate but remains significantly disabled secondary to residual lower extremity weakness and spasticity. He continues self-catheterization for persistent neurogenic bladder dysfunction. CONCLUSIONS: This represents the first case of an occult spinal DAVF becoming acutely symptomatic after lumbar disc surgery. Although the etiology of the lesion and its symptomatic progression remains unknown, an alteration of blood flow through the DAVF as a result of surgery may have resulted in progressive venous congestive myelopathy. The present case highlights the importance of considering a spinal DAVF in the differential diagnosis of any patient with signs of myelopathy or conus medullaris syndrome after lumbar discectomy. In addition, this case underscores the gravity of recognizing subtle features that suggest the presence of an occult vascular malformation on preoperative imaging, as symptomatic progression of these lesions carries significant potential morbidity.

Oncocytic Carcinoma Arising in the Submandibular Gland with Disseminated Bone Metastases.

South Med J. 2009 May 7; Lee JS, Choi JH, Oh YHOncocytic carcinoma of the head and neck is a very rare neoplasm. It usually occurs in the parotid glands. Only 11 cases of oncocytic carcinoma of the submandibular gland have been reported, and no cases have shown distant bone metastasis. A 67-year-old man presented with a tingling sensation in both hands due to a herniated cervical disc. A whole body bone scan and PET-CT showed disseminated bone metastases. Neck CT revealed a 1.7 cm calcified left submandibular mass. The submandibular gland and bone marrow biopsies were consistent with oncocytic carcinoma. Our case is the first report of oncocytic carcinoma of the submandibular gland with disseminated bone metastases.

[Ambulatory diskectomy. Safe and appreciated alternative for selected patients]

Lakartidningen. 2009 Mar 4-10; 106(10): 679-80Skeppholm M, Frost A, Olerud C

[Critical approach to diagnostics and treatment of lumbar radiculopathy]

Med Pregl. 2008 Nov-Dec; 61(11-12): 553-6Bosković KAlthough the majority of patients suffering lumbar radiculopathy have a very good prospective outcome, some 20-30% persist having problems even in two or three years time. Diagnosis is based on anamnesis and physical examination. Imaging screening with additional diagnostic methods is indicated only in patients with the extremely complicated illnesses, or in cases where the surgical intervention is inevitable. Passive (bed rest) treatment is replaced by active one. In general, there is a consensus that the initial treatment during 6-8 weeks has to be conservative. Surgical intervention of discal lesion can bring faster pain relief in patients, but in a year or two after the medical treatment, there is no clear distinction between these two approaches.

Microsurgical muscle-splitting approach for extracanalicular lumbar disc herniation: an analysis of 28 consecutive cases.

Acta Orthop Belg. 2009 Feb; 75(1): 70-4Birbilis T, Koulalis D, Matis G, Theodoropoulou E, Papaparaskeva KExtracanalicular lumbar disc herniation (ELDH) is a specific clinical entity with compression of the nerve root in its extraforaminal course. The classical midline interlaminar approach is often difficult because the facet joint obviates a direct view of the nerve, and a partial facetectomy is required. Consequently, the risk of instability or continued postoperative back pain is increased. The authors performed a microsurgical muscle-splitting approach in an attempt to obtain a direct view of the disc rupture without sacrificing the facet joint. Twenty-eight consecutive patients were operated upon with this surgical procedure. A retrospective study showed that 10 patients (35.7%) had an excellent, 13 (46.4%) a good, 4 (14.3%) a fair and one (3.6%) a poor result, according to the Macnab criteria. No serious postoperative complications were noted. This procedure is safe, effective and less invasive.

23rd Anniversary of Percutaneous Laser Disc Decompression (PLDD).

Photomed Laser Surg. 2009 May 5; Choy DS, Hellinger J, Hellinger S, Tassi GP, Lee SHAbstract Objective: In mid-February 1986, Peter Ascher and Daniel Choy performed the first percutaneous laser disc decompression (PLDD) procedure at the Neurosurgical Department, University of Graz, Graz, Austria. It was planned to deliver 1000 J of energy with an Nd:YAG laser to a herniated L4-L5 disc causing sciatica. At 600 J the procedure was terminated because the pain was gone. Background Data: Since then PLDD has spread all over the world, with procedures being performed on the entire spine except for T1-T4 because these discs do not permit percutaneous access with a needle. The success rate has ranged from 70-89%, and the complication rate, chiefly discitis, ranges from 0.3-1.0%. When successful, average time to return to normal activities is 1 wk. Long-term follow-up at 23 y yields a recurrence rate of 4-5%. Methods: Laser surgeons active in PLDD were canvassed to obtain their best clinical data. Results: PLDD patients treated with the Nd:YAG laser, the diode laser, and the combination Ho:YAG laser and endoscope were included. Conclusions: The McNab results for the three groups indicate that PLDD is safe, effective, and minimally invasive.

Cauda Equina Syndrome (CES) From Lumbar Disc Herniations.

J Spinal Disord Tech. 2009 May; 22(3): 202-206Olivero WC, Wang H, Hanigan WC, Henderson JP, Tracy PT, Elwood PW, Lister JR, Lyle LSTUDY DESIGN: A retrospective review was performed to determine the outcomes of patients with cauda equina syndrome (CES) from a herniated lumbar disc at our institutions. OBJECTIVE: CES from lumbar herniated discs is considered the only absolute indication for surgery. It is considered a neurosurgical emergency with the outcome related to how quickly it is diagnosed and treated. The results of recovery of bladder function are felt by many authors to be related to early diagnosis and surgical intervention. Most authors recommend a wide decompressive laminectomy when surgery is performed. We reviewed our cases to determine if they conformed to these assumptions. SUMMARY OF BACKGROUND DATA: Although many articles regarding the outcome of CES from herniated lumbar discs suggest that early surgery is superior to surgery that is delayed, others have demonstrated no correlation between time-to-surgery and chances for recovery of neurologic and bladder function. METHODS: A retrospective review of all patients with lumbar herniated discs and CES from the years 1985 to 2004 was carried out. There were 31 patients, 28 of whom had bladder incontinence or retention requiring catheterization. Six patients were operated within 24 hours, 8 between 24 and 48 hours, and 17 after 48 hours (range: 60 h to 2 wk). Average follow-up was 5 years. RESULTS: Twenty-seven of these patients regained continence not requiring catheterization. There was no correlation between the time-to-surgery and recovery of bladder function. There was also no correlation between the time-to-surgery and recovery of motor and sensory function. The majority of patients underwent unilateral hemilaminotomy or bilateral hemilaminotomies; decompressive laminectomy was reserved for patients with underlying spinal stenosis or posteriorly herniated fragments. All of the patients were relieved of their radicular pain. CONCLUSIONS: In our series of patients with CES and bladder incontinence or retention, over 90% regained continence. Recovery of function was not related to the time to surgical intervention. The majority of the patients were adequately treated without the need for a complete laminectomy.

Lumbar Intervertebral Disc Herniation Imaging Study

Using regional assignment to forked method to study lumbar intervertebral disc hemiation (bugle, hernia, prolapse) dependablity and reason of lumbar intervertebral disc herniation and asymptomatic lumbar intervertebral disc herniation.

METHODS: From March 2005 to October 2006, 120 patients of match condition from orthopaedics dept and rehabilitative dept of the Boai hospital of Longyan were studied. All patients were equally divided into two groups according to whether or not accompany with symptom of lumbar intervertebral disc herniation. There was not statistical difference in sex, age, course of disease, segment of intervertebral disc between two groups. Sixty patients of symptomatic lumbar intervertebral disc herniation were equally divided into three groups according to (bugle, hernia, prolapse) image on CT. Sixty patients of asymptomatic lumbar intervertebral disc herniation were equally divided into three groups according to (bugle, hernia, prolapse) image on CT. The age was 20-59 years old with an average of 38.5 years. Using regional assignment to give a mark respectively for every group. The sagittal diameter index (SI), anterior diastema of flaval ligaments, the width of superior outlet of latero-crypt, anteroposterior diameter of dura sac were respectively measured by sliding caliper. CT value and protrusible areas were respectively evaluated by computer tomography. Adopting mean value to measure three times.

RESULTS: (1) There were not statistical difference in SI, CT value, hernia areas, anteroposterior diameter of dura sac between two groups (symptomatic lumbar intervertebral disc herniation and asymptomatic lumbar intervertebral disc herniation). There were statistical difference in the width of superior outlet of latero-crypt, anterior diastema of flaval ligaments between two groups (symptomatic lumbar intervertebral disc herniation and asymptomatic lumbar intervertebral disc herniation). (2) There were statistical difference in protrusible type,protrusible segment between two groups (symptomatic lumbar intervertebral disc herniation and asymptomatic lumbar intervertebral disc herniation).

CONCLUSION: There were not necessary relationship between in protrusible size, location, type, compression degree and clinical symptom. This paper may support the mechanism of lumbar intervertebral dise herniation that associated with the following the three aspects: (1) spinal reserve capacity (SRC); (2) involved nerve roots escaping from herniated disc compression and its elastic lengthening function; (3) hypoxia symptosis and anti-ischemia injury compensation of involved nerve roots.

"Imaging study of lumbar intervertebral disc herniation and asymptomatic lumbar intervertebral disc herniation"
Zhongguo Gu Shang. 2009 Apr; 22(4): 279-82Yu QY, Yang CR, Yu L

Clinical evaluation of a lumbar interspinous dynamic stabilization device (the Wallis system) with a 13-year mean follow-up.

Neurosurg Rev. 2009 Apr 22; Sénégas J, Vital JM, Pointillart V, Mangione PThe authors determined current health status of patients who had been included in a long-term survivorship analysis of a lumbar dynamic stabilizer. Among 133 living patients, 107 (average age at surgery, 44.2 +/- 9.9 years) completed health questionnaires. All patients had initially been scheduled for decompression and fusion for canal stenosis, herniated disc, or both. In 20 patients, the implant was removed, and fusion was performed. The other 87 still had the dynamic stabilizer. Satisfaction, Oswestry disability index, visual analog scales for back and leg pain, short-form (SF-36) quality-of-life physical composite score, physical function, and social function were significantly better (p

Sources and patterns of pain in lumbar disc disease; revisiting Francis Murphey's theory.

Acta Neurochir (Wien). 2009 Apr 30; Alemo S, Sayadipour AOBJECT: Francis Murphey's theory was analyzed to determine whether or not his opinion is evidence-based medicine and whether or not it can be applied clinically. METHODS: The English literature was reviewed using Medline in reference to Dr. Murphey's theory of discogenic chronic LBP, which was first postulated in 1967. Deductive and inductive logic was utilized for the evaluation of his theory. We reviewed and analyzed his unprecedented study of the annulus fibrosus (AF) and posterior longitudinal ligament (PLL) under local anesthesia that was presented to the Congress of Neurological Surgeons in 1967 and 1972. RESULTS: He reported that: "It is found that the posterior longitudinal ligament and the remaining annulus fibrosus over the herniated discs are also exquisitely tender; even the slightest pressure on them produces pain." We noticed that in Dr. Murphey's presentation, he did not disclose any hard data, yet he concluded: "when an incomplete tear in the annulus occurs and if the tear is in the midline posterior, a fragment of nucleus will protrude in this tear, stretching the annulus and posterior longitudinal ligament, causing midline back pain. If the tear in the annulus is lateral, the pain is over the sacroiliac joint in the buttock and hip, and 20% of the patients in the lower abdomen, groin or testicle on that side." CONCLUSIONS: Because of a flaw in his understanding, in our opinion the unproven mechanical theory of discogenic LBP is weak inductive logic and does not justify discography and intra-discal procedures.

[An experimental study on the influence of radix astragali on the ressorption of ruptured disc herniation]

Zhongguo Gu Shang. 2009 Mar; 22(3): 205-7Jiang H, Liu JT, Hui RH, Wang YJOBJECTIVE: To investigate the possible mechanism of immune response in the resorption of the ruptured intervertebral disc herniation, and the possible mechanism of radix astragali on the resorption of the ruptured disc herniation. METHODS: Twenty-eight male SD (Sprague-dawley) rats were chosen. The rats were randomly divided into 4 groups: the control group, model group, the group treated with radix astragali injection and the group treated whit thymic peptide. The rats were killed and discs were harvested 10 days after treatment. Flow cytometry and HE staining were used for analysis of cells and tissue. RESULTS: Compared with the control group, the proportion of activated T cells (CD4+ and CD8+) and B cells were significantly higher in the two drug-treatment groups. CONCLUSION: Herniated nucleus pulposus attracts activated T and B cells and triggered an immune response. Radix astragali could strengthen the autoimmune response.

Sagittal alignment as a risk factor for adjacent level degeneration: a case-control study.

Orthopedics. 2008 Jun; 31(6): 546Djurasovic MO, Carreon LY, Glassman SD, Dimar JR, Puno RM, Johnson JRThis study examined whether sagittal alignment, preexisting adjacent level degeneration, and smoking predispose patients to adjacent segment degeneration following lumbar fusion. Fifty-one patients with adjacent segment degeneration were identified and matched with control patients based on age, sex, level, and date of index surgery. Preexisting adjacent level degeneration and sagittal alignment through the fusion and from L1-S1 were determined before and after initial surgery. Patients with adjacent segment degeneration had significantly less lordosis through the fusion and lumbar spine following their initial surgery. There was no significant difference in the amount of preexisting adjacent level degeneration and smoking between the adjacent segment degeneration and control groups. Fusion of the lumbar spine in abnormal sagittal alignment, with loss of lumbar lordosis, predisposes patients to the development of adjacent segment degeneration. Adjacent segment degeneration does not appear to be just a progression of preexisting degenerative changes at the adjacent level.

Very late drug-eluting stent thrombosis after nonsteroidal anti-inflammatory drug treatment despite dual antiplatelet therapy.

Can J Cardiol. 2009 Apr; 25(4): 229-32Merkely B, Tóth-Zsamboki E, Becker D, Beres BJ, Szabó G, Vargova K, Fülöp G, Kerecsen G, Preda I, Spaulding C, Kiss RGBACKGROUND: Drug-eluting coronary stent implantation emerged as a safe and effective therapeutic approach by preventing coronary restenosis and reducing the need for further revascularization. However, in contrast to bare metal stents, recent data suggest a unique underlying pathology, namely late coronary stent thrombosis and delayed endothelial healing. OBJECTIVE: To report a case of very late coronary stent thrombosis (834 days after implantation) requiring repeat urgent target-vessel revascularization. Importantly, six days before the acute coronary event, combined nonsteroidal anti-inflammatory drug therapy was initiated. RESULTS: Although a dual antiplatelet regimen was continuously maintained, aggregation measurements indicated only partial antiplatelet effect, which returned to the expected range when nonsteroidal anti-inflammatory drugs were omitted. CONCLUSIONS: The observation indicates that, even 834 days after drug-eluting stent implantation, effective combined antiplatelet therapy might be crucial in certain individuals and the possible impact of drug interactions should not be underestimated. Further efforts should focus on the challenging task of identifying patients or medical situations with prolonged, increased risk of stent thrombosis.

Posterior pelvic pain provocation test is negative in patients with lumbar herniated discs.

Eur Spine J. 2009 Apr 24; Gutke A, Hansson ER, Zetherström G, Ostgaard HCThe classification of pelvic girdle pain can only be reached after lumbar causes have been excluded by a clinical examination. During clinical examination, the posterior pelvic pain provocation test is a well-established method for verifying pelvic girdle pain. However, a criticism of pelvic pain provocation tests is that they may have an effect on lumbar structures, thus yielding false-positive results. The posterior pelvic pain provocation test was performed with four groups of patients: patients with computed tomography-verified disc herniations (1) on the waiting list for surgery (14 women; 9 men); (2) 6 weeks after disc surgery (18 women, 12 men); (3) pregnant women seeking care for pelvic girdle pain (n = 25); and (4) women with persistent pelvic girdle pain after delivery (n = 32). The sensitivity of the posterior pelvic pain provocation test was 0.88 and the specificity was 0.89. The positive predictive value was 0.89 and the negative predictive value was 0.87. Analysis of only women showed similar results. In our study, the posterior pelvic pain provocation test was negative in patients with a well-defined lumbar diagnosis of lumbar disc herniation, both before and after disc surgery. Our results are an important step toward the more accurate classification of lumbopelvic pain.

Sporting activity following discectomy for lumbar disc herniation.

Orthopedics. 2008 Aug; 31(8): 756Dollinger V, Obwegeser AA, Gabl M, Lackner P, Koller M, Galiano KThe aim of this study was to investigate to what extent patients could resume physical activity following surgery for herniated lumbar disks. We analyzed a cohort of 1003 patients who underwent lumbar spine surgery within 1 year. Out of this cohort, 93 patients were selected according to our inclusion criteria (age 20-35 years, mediolateral single level disk herniation, no comorbidity at the lumbar spine, and treatment with conventional subtotal diskectomy). This group was evaluated after a minimum follow-up of 28 months in a telephone questionnaire; participants were questioned about pre- and postoperative physical activities. The questionnaire was answered by 67 patients. Twenty-six patients were lost to follow-up because they had relocated. The follow-up group had a mean age of 30 years. Five patients underwent a second procedure due to recurrent disk herniation. All patients showed a pain reduction. At follow-up, no patient needed constant pain medication. Eighty-two percent of the patients were pain free during practicing sports. Sixty-two patients performed some type of sport after surgery. Concerning the type and frequency of physical activities, no significant change between pre- and postoperative behavior occurred. The 5 patients with recurrent disk herniation did not behave differently. Single-level lumbar disk surgery does not limit or compromise sportive activity in young people.

Delayed hyper-reactivity to metal ions after cervical disc arthroplasty: a case report and literature review.

Spine. 2009 Apr 1; 34(7): E262-5Cavanaugh DA, Nunley PD, Kerr EJ, Werner DJ, Jawahar ASTUDY DESIGN: Anecdotal case report. OBJECTIVE: To report a very interesting and perplexing complication of cervical total disc arthroplasty that has not been previously reported in literature. SUMMARY OF BACKGROUND DATA: Although there has been increasing interest in the field of artificial disc replacement to treat cervical degenerative disc disease, not much has been mentioned in the literature about the potential complications of the disc itself. We encountered a delayed complication in 1 patient that has not been reported in the literature. METHOD: Thirty-nine-year-old white woman received total disc arthroplasty for herniated intervertebral disc at C5-C6 level uneventfully. She had recurrence of symptoms 9 months after the procedure and failed to respond to conservative measurements. Imaging revealed soft tissue mass posterior to the implanted disc encroaching the spinal cord. RESULTS: Surgical explantation and exploration of the disc space revealed thick layer of abnormal hyaline cartilaginous tissue with chronic inflammatory debris. The patient had complete resolution of symptoms after the revision surgery. CONCLUSION: Although there is increased enthusiasm about motion preservation technology and disc replacement surgery for intervertebral disc herniation, unexpected complications like the present case need to be shared within the scientific community to better understand the risks associated with these new and promising devices.

Results of Microendoscopic Discectomy Performed in the 26 Cases with a Minimum 3 Years Follow-up.

Chang Gung Med J. 2009 Jan-Feb; 32(1): 89-97Chang SS, Fu TS, Liang YC, Lia PL, Niu CC, Chen LH, Chen WJBackground: Microendoscopic discectomy (MED) is less invasive than conventional open discectomy, but the long-term benefits of this technique are still debated. Controversy also remains regarding the surgical indications, patient selection, effectiveness, learning curve and complications. Methods: From Dec 2001 to Dec 2003, 26 patients with lumbar herniated disc disease received MED. The surgical indications included the following: (1) unilateral, single level lumbar disc herniation; (2) signs and symptoms compatible with the involved nerve root; (3) failure of conservative treatment. These cases were the initial MEDs performed by one of our senior authors (TS FU). Clinical symptoms and outcomes were assessed using the Japanese Orthopaedic Association Back Scores. Results: Treatment in two cases was changed to open discectomy because of irreparable dural tears during surgery. For the remaining 24 cases, the average intraoperative blood loss was 55.8 mL. The average operation length was 136.8 minutes and the average post-surgical hospital stay was 2.4 days. At 12 weeks after the operation, 22 achieved excellent or good results. The satisfactory rate was 91.7%. On final follow-up, 21 patients had excellent or good results. The satisfactory rate was 87.5%. Complications included two irreparable dural tears, two superficial wound infections and one pseudomenigocele. Conclusions: Our data indicate that MED is an effective procedure for lumbar disc herniation. The result is satisfactory under adequate surgical indications and patient selection. Despite the low complication rate, dural tears still remain a concern during the learning stage.